A 54 year old female with a BMI of 25.9 comes for her regular hypertension clinic visit. Today, blood work reveals an HbA1c of 8.7 (normal less than 6.5). Over the past 4 months she has gained 22 pounds and 3 weeks ago she sustained the injury (shown in the image) after a minor fall. Her blood pressure is 155/90, P 90, RR 14 and T 98.7.
At the moment she is on enalapril, furosemide and diltiazem. What is the next step in her management?
A. Send her for a bariatric consult
B. Order a 24 hour urine cortisol test
C. Refer to physical therapy for an exercise plan
D. Refer to an endocrinologist for management of blood glucose
E. Send urine for metanephrines
F. Dietary consult
Answer B
1. The patient has all the features of excess corticosteroids including Colles fracture as a result of osteoporosis.
2. The most common endogenous cause of Cushing's syndrome is Cushing's disease. Frequent clinical findings include weight gain, truncal obesity, striae, hypertension, glucose intolerance and infections.
3. The best screening test for Cushing's syndrome is a 24-hour urine collection with analysis for urinary free cortisol excretion.
4. Low-dose and high-dose dexamethasone suppression tests, corticotropin assays, a corticotropin-releasing hormone stimulation test and inferior petrosal sinus catheterization may be required for a definitive diagnosis.
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