Pharm MCQs

 Q1. A patient undergoing chemotherapy is started on an antiemetic that acts at the site ‘E’ shown in the image below. The drug is?

a. Morphine

b. Chlorpromazine

c. Imipramine

d. Apomorphine

e. Metoclopramide

f. Prednisone

For answer & rest of the case-

https://youtu.be/MH-2aKkQ5tg

Case- Guaiac positive stools

 Q1. A 65-year-old female presents with generalized fatigue and malaise of 3 months duration. Lately she has been feeling dizzy, has no appetite, easily runs out of breath and  has to use a laxative every other day. Other than smoking, she has no other medical history. She is a retired schoolteacher. Her meds include an inhaler and multivitamins. Physical exam is unremarkable. The results of the digital rectal and stool Guaiac test are shown - see image.  What is a very common cause of a false negative with this test? 

a. Red meat

b. Green veggies

c. Iron supplements

d. Citrus fruits

e. Use of laxatives

f. Starvation

For answer & rest of the case

https://youtu.be/M7pU5fKSrUU

Pharm MCQs

 Which of the following agents will bind to the purine base shown in the image and cause the changes observed?

a. Azathioprine

b. Vincristine

c. Cyclosporine

d. Cisplatin

e. Paclitaxel

Answer D

1. An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to DNA.

2. The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the purine ring.

3. Cisplatin is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell cycle non-specific.

4. They stop tumor growth by cross linking guanine nucleobases in DNA double-helix strands, directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act non-specifically.

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Pharm MCQS