A 27-year old male presents with complaints of general malaise, fever, vague joint and muscle pain that have been going on for about 12 weeks. Last 4 days, he has had 2 episodes of hemoptysis and coughing spells. He claims that he has never had an appetite for food and was never able to participate in sports because he was always short of breath. He has been to many healthcare providers but no cause was ever found. On physical, his vitals are BP 160/95, P 110, RR 26 and T 99.8 F. Auscultation reveals crackles bilaterally. He has mild pedal edema. Blood work reveals elevated BUN and creatinine levels with a mild leucocytosis. The urine shows microscopic hematuria and red cell casts. The patient is admitted and referred to a nephrologist who performs a kidney biopsy. The immunofluorescence stain is shown in the image. Five days later, the patient develops massive hemoptysis and his blood pressure is 90/55. The patient’s arterial blood gas is pH 7.21, PO2 87, PCO2 50 and bicarbonate 18.3. What is your next step in the management of this patient?

A. Hemodialysis
B. Plasmapheresis
C. Immediate Thoracotomy
D. Angiographic embolization
E. Start corticosteroids IV
1. Goodpasture disease is rare cause of glomerulonephritis and may present with or without pulmonary hemorrhage
2. The key laboratory feature is the presence of circulating anti–glomerular basement membrane (anti-GBM) antibodies. This binding of antibodies can be visualized as the linear deposition of immunoglobulin along the glomerular basement membrane and, less commonly, the alveolar basement membranes, by direct immunofluorescent techniques.
3. In many studies, plasmapheresis has been shown to be beneficial in the treatment of Goodpasture syndrome by removal of anti-GBM antibodies. Plasmapheresis is usually performed after the diagnosis of Goodpasture syndrome is established either by renal biopsy or by detection of anti-GBM antibodies.
4. When a patient presents in a life-threatening situation secondary to pulmonary hemorrhage, however, plasmapheresis may be initiated if the diagnosis appears very likely, even though confirmation is not available immediately.