Pharm MCQs

 Which of the following agents will bind to the purine base shown in the image and cause the changes observed?

a. Azathioprine

b. Vincristine

c. Cyclosporine

d. Cisplatin

e. Paclitaxel

Answer D

1. An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to DNA.

2. The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the purine ring.

3. Cisplatin is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell cycle non-specific.

4. They stop tumor growth by cross linking guanine nucleobases in DNA double-helix strands, directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. These drugs act non-specifically.

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Pharm MCQS

Med & Surg MCQs

 Q1.A 49 year old male presents with dyspnea and general malaise of 2 months duration. He denies any travel, allergies or injury. However, he does report fever and a sore throat several months ago. He is on no medications but is a heavy smoker and drinks alcohol regularly. Blood work is pending. His Chest x-ray is shown. What is your working diagnosis? 

a. Ruptured esophagus

b. Lung mass

c. Post pneumonic effusion

d. Chylothorax

e. CHF

f. Tuberculosis

For more on the case and answer

https://youtu.be/V2LHQYpnH1Y

Med & Surg Case Scenario

 Q1. A 27 yo with no significant past medical history presents with a cough, dyspnea and chest discomfort of 4 weeks duration. He revealed an URTI about 6 weeks ago which spontaneously resolved.  His past medical history is unremarkable, he denies smoking and has no allergies. Vital signs are normal and the exam reveals rubbery nodules in the left neck. His chest x-ray is shown.  The radiologist feels that there is a mass lesion in the mediastinum. Which of the following is the least likely cause of his symptoms?

a. Thymoma

b. Thyroid

c. Teratoma

d. Lymphoma

e. Pheochromocytoma

For more on the case and answers

https://youtu.be/V2LHQYpnH1Y

Med & Infect Disease MCQs

 While on a trip to Hawaii, a teenager swallowed the creature shown in the image. The 16-year then returned back to this home in NY only to develop nausea, vomiting, and severe abdominal cramps a few days later. Over the next few days, the GI symptoms eased but then he developed a fever, headache, and stiffness of the neck. He presented to the ED where he was found to have facial nerve palsy on the right side. A lumbar puncture revealed marked eosinophilia but the fluid was negative for any organisms. All other workup was negative. He was admitted and monitored in the ICU. Because the patient was showing gradual clinical improvement, no antibiotics were administered. The infectious disease expert felt that the infection may have been due to a parasite endemic to the Hawaii and Pacific region. By the end of 2 weeks, all the symptoms had resolved and the patient was discharged. Based on the history and presentation, what is the definitive HOST for this parasite?

A. Mosquito

B. Pig

C. Rat

D. Bird

For answer & explanation

https://www.youtube.com/watch?v=r4pKz1yji8w